Page 59 - Magyar Gasztroenterológiai Társaság 2020. november 6–7. – ONLINE KONGRESSZUS

Előadáskivonatok / Abstracts

transmembrane conductance regulator (CFTR) in the normal Conclusion: The EUS-guided liver biopsy is a safe
immune response. These findings were further strengthened procedure with good diagnostic accuracy.
by clinical studies revealing the accumulation of certain
autoimmune diseases, such as celiac disease (CeD), among 67. UTILITY OF MULTIPLE RAPID SWALLOWING TEST
patients with cystic fibrosis (CF). Inspired by these, we aimed IN EVALUATION OF PATIENTS WITH GERD
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to evaluate the prevalence of CeD and CeD-related Izbéki F. , Joó I. , Wágner I. , Józsa A. , Boros E. , Kapitány
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autoantibody positivity in CF. D. , Minárik A. , Jurenka Z. , Altorjay Á.
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Methods: A systematic literature search was conducted in 5 1. 1st Department of Medicine, Gastroenterology and
databases for studies which reported about CeD and/or CeD- Hepatology, Szent György Teaching Hospital of County
related autoantibody positivity among CF patients. CeD was Fejér; 2. Department of Surgery, Szent György County
defined as per the current guidelines and needed to be Hospital of County Fejér
confirmed with intestinal biopsy. Antibodies of interest
included tissue transglutaminase antibody (TGA) and anti Introduction: Multiple rapid swallowing test (MRST) is used
endomysial antibody (EMA). We calculated raw prevalence to assess oesophageal peristaltic reserve during high-
with 95% confidence intervals (CI) in meta-analysis. resolution manometry (HRM)
Heterogeneity was tested by means of I 2 and chi 2 tests. Aims: Our aim was to evaluate the relationship between
Results: Altogether, 15 publications reported the prevalence MRST response and parameters of 24-hour pH impedance
of CeD in CF. Out of these, 6 performed consecutive monitoring (MII) in patients evaluated for PPI refractory reflux
population screening, resulting in a pooled prevalence of disease.
1.8% (CI 1.2-2.6%), while another 8 provided the prevalence Methods: MRST have been performed in our laboratory for
of CeD based on medical history with a pooled prevalence of 2 years as part of routine HRM by administering 5 swallows
2.3% (CI 1.1-4.7%). TGA positivity and TGA-EMA double of water at 2-3 second intervals at the end of the study.
positivity were detected in 4.5% (CI 2.9-6.9%) and 2.4% (CI Peristaltic reserve was considered normal if the ratio of post
1.4-4.1%) of CF patients, respectively. MRS distal contractile integral (DCI) and the mean DCI of 10
Conclusion: Based on consecutive screening studies, the wet swallows was greater than 1. We retrospectively
pooled prevalence of CeD seems significantly higher in CF evaluated the HRM and MII recordings in 57 patients
(1.8%) compared to the worldwide prevalence (0.5-0.9%). evaluated for PPI refractory reflux disease. MII recordings
These results imply that CF patients might benefit from were done off-PPI.
screening for CeD. The underlying pathomechanism requires Results: There were 25 patients with normal (nMRST) and
further investigation. 32 patients with an abnormal one (aMRST). DCI was
significantly lower in patients with aMRST than in patients
66. ENDOSCOPIC ULTRASONOGRAPHY-GUIDED LIVER with nMRST. The number of reflux events and the acid
BIOPSY – SINGLE CENTER EXPERIENCES exposure time were also significantly higher in patients with
Ivány E. , Illés D. , Kui B. , Lemes K. , Tajti M. , Bor R. , aMRST. The proximal extent of reflux was also significantly
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Fábián A. , Szepes Z. , Czakó L. more frequent in patients with aMRST.
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1. First Department of Internal Medicine, University of Conclusion: MRST could be a useful additional marker to
Szeged improve the ability of HRM to detect clinically relevant
oesophageal dysfunction in patients with abnormal
Introduction: Liver biopsy is an important method in the oesophageal acid exposure.
diagnosis of hepatic diseases. It can be performed 68. SCREENING METHODS FOR CYSTIC FIBROSIS-
percutaneously without image guidance or an ultrasound- or RELATED DIABETES - A NETWORK META-ANALYSIS
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CT-guided manner. Nowadays endoscopic ultrasound- Izsák V. , Soós A. , Szakács Z. , Hegyi P. , Juhász F. ,
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guided (EUS-guided) sampling technique is a spreading Varannai O. , Martonosi Á. , Földi M. , Kozma A. ,
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option. Párniczky A.
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Aims: To collect retrospective data about EUS-guided liver 1. Institute for Translational Medicine, Medical School,
biopsy experiences at the University of Szeged. University of Pécs; 2. Heim Pál National Institution of
Methods: Patients undergoing EUS examations were Pediatrics; 3. János Szentágothai Research Center,
collected from 2016 until nowadays when liver biopsy was University of Pécs,
performed. An Olympus GF-UCT-140 endoscope was used
in our center. Midazolam, lidocaine and hyoscine Introduction: Improved life expectancy of cystic fibrosis
buthilbromide were administered as premedication. Fine (CF) patients has led to an increase in the prevalence of
needle aspiration was done from the stomach using different other complications, such as CF-related diabetes (CFRD).
sizes of EZ Shot aspiration needles. Smears for cytological Currently used gold standard screening tool is the oral
evaluation and histological samples were also obtained. The glucose tolerance test (OGTT) which is recommended to
quality of collected samples and thee diagnostic accuracy of perform anually in all non-diabetic CF patients above the age
live EUS-FNA were analysed. 10.
Results: In the examined period EUS-guided liver biopsy Aims: We aimed to evaluate that these modalities may be
was done in 51 cases. The average age of the 30 male and potential alternatives for OGTT by performing a Bayesian
21 female patients was 66.3±11.5 years. In every case the diagnostic test accuracy network meta-analysis.
indication was to examine pancreatic or hepatic lesions Methods:We conducted a systematic search in five
diagnosed with another imaging technique. Mostly 22 G databases (MEDLINE, Embase, Web of Science, Scopus,
needle was applied (35 cases). The biopsy was done through CENTRAL). Eligible papers included study subjects
the stomach. The avarage size of the sampled lesions was previously diagnosed with CF and compared several
29.1±19.6 mm. Most lesions were metastases, mostly diagnostic methods (as index tests), including Hemoglobin
pancreatic origin, but neuroendocrine, metastase of breast or A1c (HbA1c) or continuous glucose monitoring (CGM) to
lung cancer was also identified. No complication appeared OGTT (as reference standard).
during or after the procedure.
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Central European Journal of Gastroenterology and Hepatology 57
Volume 6, Supplementum 2 / November 2020