Page 60 - Magyar Gasztroenterológiai Társaság 2020. november 6–7. – ONLINE KONGRESSZUS

Előadáskivonatok / Abstracts

After data collection by two independent authors, we created
After data collection by two independent authors, we created Introduction: 10-30% of patients with acute pancreatitis
2x2 tables including true positive (TP), false positive (FP),
true negative (TN) and false negative (FN) cells. Introduction: 10-30% of patients with acute pancreatitis
2x2 tables including true positive (TP), false positive (FP),
(AP) develop recurrent acute pancreatitis (RAP) and a third
true negative (TN) and false negative (FN) cells. 36 patients
Results: Altogether, 27 papers reporting on 12 (AP) develop recurrent acute pancreatitis (RAP) and a third
of those with RAP develop chronic pancreatitis (CP). Due to
the lack of randomized control trials recent international
Results: Altogether, 27 papers reporting on 1236 patients 7
were eligible for inclusion. The network consisted of of those with RAP develop chronic pancreatitis (CP). Due to
guidelines failed to include recommendations aimed at
diagnostic modalities (which were reported at least in two the lack of randomized control trials recent international
were eligible for inclusion. The network consisted of 7
guidelines failed to include recommendations aimed at
diagnostic modalities (which were reported at least in two
studies) including CGM for different days (from 1 to 7), decreasing recurrences. In the everyday practice - without
decreasing recurrences. In the everyday practice - without
studies) including CGM for different days (from 1 to 7), evidence - a low-fat diet is often favored after AP or between
HbA1c, and etc. According to the ranking by superiority
attacks of RAP to avoid subsequent attacks.
indices CGM for 1-3 days was ranked the highest. HbA1c,
HbA1c, and etc. According to the ranking by superiority evidence - a low-fat diet is often favored after AP or between
attacks of RAP to avoid subsequent attacks.
which is a commonly used, cheap, screening tool, was only Aims: Our aim is to provide a high level of evidence
indices CGM for 1-3 days was ranked the highest. HbA1c,
which is a commonly used, cheap, screening tool, was only Aims: Our aim is to provide a high level of evidence
concerning nutritional interventions in RAP in order to
ranked at the third place after CGM.
prevent further episodes of pancreatitis.
ranked at the third place after CGM. GM might be a potential
Conclusion: Based on our results, C concerning nutritional interventions in RAP in order to
prevent further episodes of pancreatitis.
Conclusion: Based on our results, CGM might be a potential
alternative for OGTT while we must be aware that it has its Methods: The Hungarian Pancreatic Study Group
drawbacks (such as the cost and inconvenience of the
alternative for OGTT while we must be aware that it has its (HPSG)has launched the EFFORT-(Effect of dietary fat
Methods: The Hungarian Pancreatic Study Group
drawbacks (such as the cost and inconvenience of the (HPSG)has launched the EFFORT-(Effect of dietary fat
content on the recurrence of pancreatitis), prospective, triple-
device).
69. VITAMIN D SUPPLEMENTATION IN PATIENTS WITH
device). content on the recurrence of pancreatitis), prospective, triple-
armed, randomized-controlled trial. 576 eligible patients with
non-alcoholic and non-biliary RAP (at least 2 episodes in the
CYSTIC FIBROSIS: A SYSTEMATIC REVIEW AND META-
69. VITAMIN D SUPPLEMENTATION IN PATIENTS WITH armed, randomized-controlled trial. 576 eligible patients with
preceding 2 years) will be randomized to one of the following
CYSTIC FIBROSIS: A SYSTEMATIC REVIEW AND META- non-alcoholic and non-biliary RAP (at least 2 episodes in the
ANALYSIS
1
1
ANALYSIS , Varannai O. , Németh D. , Szakács Z. , Kiss diets with different fat contents: (1) ‘reduced fat diet’ (15%
Juhász M.
1
1,2
preceding 2 years) will be randomized to one of the following
S. , Izsák V. , Martonosi A. , Hegyi P. , Párniczky A. fat), (2) ketogenic diet (75%), (3) ‘standard healthy diet’
Juhász M. , Varannai O. , Németh D. , Szakács Z. , Kiss
1 1,2
1
1,2
1
1 1,3
1,2 1,2
diets with different fat contents: (1) ‘reduced fat diet’ (15%
1
1,2
1,3
1,2
(30%). Participants will be followed-up for 2 years during
1,2
S. , Izsák V. , Martonosi A. , Hegyi P. , Párniczky A. fat), (2) ketogenic diet (75%), (3) ‘standard healthy diet’
1. Institute for Translational Medicine, Medical School,
1. Institute for Translational Medicine, Medical School,
which they will receive repeated sessions of nutritional
University of Pécs, Pécs, Hungary; 2. Heim Pál National (30%). Participants will be followed-up for 2 years during
Institution of Pediatrics, Budapest, Hungary; 3. János guidance. Endpoints are: all-cause AP recurrence, CP,
which they will receive repeated sessions of nutritional
University of Pécs, Pécs, Hungary; 2. Heim Pál National
mortality,
specific
mortality,
all-cause
pancreatitis
Szentágothai Research Center, University of Pécs, Pécs, guidance. Endpoints are: all-cause AP recurrence, CP,
Institution of Pediatrics, Budapest, Hungary; 3. János
pancreatitis
Hungary
Szentágothai Research Center, University of Pécs, Pécs, cardiosvascular (CV) mortality, all-cause mortality,
specific events, CV cause mortality, weight,
Hungary body mass index, serum lipid parameters, adherence to
cardiosvascular (CV) events, CV cause mortality, weight,
Introduction: Pancreas exocrine insufficiency (PEI) occurs body mass index, serum lipid parameters, adherence to
dietary recommendations, adverse events.
in 85-90% of patients with cystic fibrosis (CF) resulting in
Introduction: Pancreas exocrine insufficiency (PEI) occurs Conclusion: The EFFORT-trial aims to provide a high level
dietary recommendations, adverse events.
protein and fat malabsorption, failure to thrive, poor weight
in 85-90% of patients with cystic fibrosis (CF) resulting in Conclusion: The EFFORT-trial aims to provide a high level
of evidence on dietary intervention in non-biliary, non-
gain and deficiency of macro- and micronutrients. Despite
protein and fat malabsorption, failure to thrive, poor weight of evidence on dietary intervention in non-biliary, non-
alcoholic RAP. Based on our results an evidence-based
routine supplementation vitamin D deficiency is often seen in alcoholic RAP. Based on our results an evidence-based
gain and deficiency of macro- and micronutrients. Despite
nutritional recommendation could be stated and incorporated
routine supplementation vitamin D deficiency is often seen in
CF. D hypovitaminosis can lead to skeletal complications and into international treatment guidelines in order to prevent
nutritional recommendation could be stated and incorporated
into international treatment guidelines in order to prevent
CF. D hypovitaminosis can lead to skeletal complications and
increases the frequency of pulmonary exacerbations. relapses of AP.
increases the frequency of pulmonary exacerbations.
Aims: We aimed to assess the effects of vitamin D relapses of AP.
Aims: We aimed to assess the effects of vitamin D
supplementation on vitamin D levels, respiratory outcomes 71. CHANGE IN MUCOSAL SERPIN E1 EXPRESSION
supplementation on vitamin D levels, respiratory outcomes
RESPONSE
and the safety of vitamin D administration in CF. 71. CHANGE IN MUCOSAL SERPIN E1 EXPRESSION
THERAPEUTIC
IN
REFLECTS
REFLECTS
THERAPEUTIC
RESPONSE
and the safety of vitamin D administration in CF. RCTs that
Methods: In this meta-analysis, we included INFLAMMATORY BOWEL DISEASE PATIENTS IN
INFLAMMATORY BOWEL DISEASE PATIENTS , Kata D. ,
compared vitamin D supplementation (any dose, form and
Methods: In this meta-analysis, we included RCTs that Jójárt B. 1,3,4 , Szabó V. 1,3,4 , Varga A. 1,3,4 , Szántó K. 1 5
Földesi I.
1,3,4
, Szabó V., Maléth J.
5
1
, Szántó K. , Kata D. ,
compared vitamin D supplementation (any dose, form and Jójárt B. , Molnár T. 1 1,3,4 , Varga A. , Farkas K. 1 5
duration) with placebo (i.e. ‘non-increased dose’) in CF
1,2,3,4
1,3,4
patients (regardless of age and comorbidities). We
duration) with placebo (i.e. ‘non-increased dose’) in CF Földesi I. , Molnár T. , Maléth J. 1,2,3,4 , Farkas K. of Medicine,
5
1
1. First Department of Medicine, Faculty
1
conducted a systematic search in 4 databases: Embase, 1. First Department of Medicine, Faculty of Medicine,
University of Szeged; 2. Department of Public Health, Faculty
patients (regardless of age and comorbidities). We
University of Szeged; 2. Department of Public Health, Faculty
MEDLINE, CENTRAL and Web of Science. No filters were of Medicine, University of Szeged; 3. Hungarian Academy of
conducted a systematic search in 4 databases: Embase,
applied and there were no restrictions based on language, of Medicine, University of Szeged; 3. Hungarian Academy of
MEDLINE, CENTRAL and Web of Science. No filters were
Science - University of Szeged Momentum Epithelial Cell
country of origin, and date. Weighted mean differences Science - University of Szeged Momentum Epithelial Cell
applied and there were no restrictions based on language,
Signaling and Secretion Research Group; 4. Hungarian
country of origin, and date. Weighted mean differences
(WMD) with 95% confidence intervals (CI) were calculated. Signaling and Secretion Research Group; 4. Hungarian
Centre of Excellence of Molecular Medicine – University of
Szeged Molecular Gastroenterology Research Group; 5.
(WMD) with 95% confidence intervals (CI) were calculated.
Results: EightRCTs were eligible for inclusion. The Centre of Excellence of Molecular Medicine – University of
Institute of Laboratory Medicine, Faculty of Medicine,
Results: EightRCTs were eligible for inclusion. The Szeged Molecular Gastroenterology Research Group; 5.
intervention group had significantly higher se25OHD levels
(WMD: 10.48 ng/ml, CI: 0.72-20.24 ng/ml). There were no
intervention group had significantly higher se25OHD levels Institute of Laboratory Medicine, Faculty of Medicine,
University of Szeged
(WMD: 10.48 ng/ml, CI: 0.72-20.24 ng/ml). There were no
significant differences found in the quantitative synthesis of University of Szeged

significant differences found in the quantitative synthesis of Introduction: Inflammatory bowel diseases are chronic
clinical outcomes, including bone disease-related outcomes,
clinical outcomes, including bone disease-related outcomes, Introduction: Inflammatory bowel diseases are chronic
mortality, respiratory and immunological status-related
gastrointestinal disorders. Biologic therapies are primary
outcomes. treatment options in IBD, but in 40-60% of cases the patients
gastrointestinal disorders. Biologic therapies are primary
mortality, respiratory and immunological status-related
don’t respond or lose response over time. Imbalance
outcomes.
Conclusion: In the present meta-analysis, a higher vitamin treatment options in IBD, but in 40-60% of cases the patients
don’t respond or lose response over time. Imbalance
D dose resulting in significantly greater se25OHD levels did homeaostasis of cytokines alter inflammatory response and
Conclusion: In the present meta-analysis, a higher vitamin
determine response to therapy. Thus, patient-specific
D dose resulting in significantly greater se25OHD levels did
not seem to improve clinical outcomes significantly, this can homeaostasis of cytokines alter inflammatory response and
not seem to improve clinical outcomes significantly, this can
be due to the heterogeneous outcome choices across the determine response to therapy. Thus, patient-specific
determination of individual cytokine profiles could improve
be due to the heterogeneous outcome choices across the determination of individual cytokine profiles could improve
studies, the low sample size and differences in populations.
the prediction of therapeutic response.
studies, the low sample size and differences in populations. Aims: Our aim was to determine cytokine profile of IBD
the prediction of therapeutic response.

70. THE EFFECT OF DIETARY FAT CONTENT ON THE Aims: Our aim was to determine cytokine profile of IBD
patients and characterize expression of promising cytokines.
70. THE EFFECT OF DIETARY FAT CONTENT ON THE Methods: Biopsies were obtained from inflamed part of
patients and characterize expression of promising cytokines.
RECURRENCE OF PANCREATITIS – PRE-STUDY
Methods: Biopsies were obtained from inflamed part of
OF
THE
EFFORT-RANDOMIZED
PROTOCOL
RECURRENCE OF PANCREATITIS – PRE-STUDY colon of IBD patients and controls. Total protein and mRNA
PROTOCOL OF L THE EFFORT-RANDOMIZED were isolated from biopsy samples. Cytokine Array was used
colon of IBD patients and controls. Total protein and mRNA
CONTROLLED TRIA
were isolated from biopsy samples. Cytokine Array was used
1
Juhász M. , Ocskay K. 1 1 1 1 to analyse cytokine expression. SerpinE1 levels were
CONTROLLED TRIAL , Farkas N. , Szakács Z. , Zádori N. ,
1 1,3
Párniczky A. , Hegyi P. 1 1 1 measured by ELISA.
Juhász M. , Ocskay K. , Farkas N. , Szakács Z. , Zádori N. ,
to analyse cytokine expression. SerpinE1 levels were
1
1,2
1,3
Results: We defined
Párniczky A. , Hegyi P.
1,2
1. Institute for Translational Medicine, Medical School, measured by ELISA. cytokine profile of 36 biopsy samples.
University of Pécs, Pécs, Hungary; 2. Heim Pál Children’s In samples of IBD we identified the expression of MIP1-α/β,
1. Institute for Translational Medicine, Medical School,
Results: We defined cytokine profile of 36 biopsy samples.
University of Pécs, Pécs, Hungary; 2. Heim Pál Children’s In samples of IBD we identified the expression of MIP1-α/β,
Hospital, Budapest, Hungary; 3. János Szentágothai
IL-1β, IL-8, IL-18 and SerpinE1. SerpinE1/PAI-1 activates
coagulation, whereas the risk to develop deep venous
Hospital, Budapest, Hungary; 3. János Szentágothai
Research Center, University of Pécs, Pécs, Hungary IL-1β, IL-8, IL-18 and SerpinE1. SerpinE1/PAI-1 activates
Research Center, University of Pécs, Pécs, Hungary coagulation, whereas the risk to develop deep venous
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58 Central European Journal of Gastroenterology and Hepatology
Volume 6, Supplementum 2 / November 2020