Page 56 - Magyar Gasztroenterológiai Társaság 2020. november 6–7. – ONLINE KONGRESSZUS

Előadáskivonatok / Abstracts

Medicine, Medical School, Szentágothai Research Centre, study, repetitive injections of cerulein were applied to mimic
University of Pécs, Pécs, Hungary the CP development via recurrent attacks.
Results. In the AP registry, 983 patients had a single attack
Background: Rising prevalence of cirrhotic cases related to of AP(non-CP), 304 had earlier attacks (RAP2-14,non-CP),
non-alcoholic steatohepatitis has led to an increased number whereas 62 had earlier developed CP. 0% of CP was
of cirrhotic patients with the coexistence of obesity and diagnosed among patients with a single AP episode, 1% with
muscle mass loss called as sarcopenic obesity (SO). In RAP2, 16% with RAP3, and 50% with RAP4+. Fifteen of the
patients undergoing liver transplantation (LT), the presence investigated factors (epidemiology-, etiology-, laboratory-
of SO may worsen prognosis and increase morbidity and and pancreas-based parameters) were significantly different
mortality. We aimed to evaluate the effect of the presence of in the first attack of AP and CP. However, the significance
pre-transplant SO on the outcomes of LT. disappeared after repetitive attacks (9 biomarkers after
Methods: A comprehensive search was performed in seven RAP2, 4 after RAP3 and 2 after RAP3+). RAP patients had
medical databases for studies comparing morbidity and an average of 3.07±1.85, whereas CP patients had
mortality of patient with SO to patients without SO (non-SO) 3.76±2.24 episodes of AP. In the CP registry, 98% of patients
after LT. The primary outcome was overall mortality on short- with CP had more than one acute episode, and the average
(1 year), intermediate- (3 years), and long-term (5 years). number of attacks was 4-5 (4.07±3.82). The experimental
Pooled relative risks (RRs) with 95% confidence intervals data revealed that the significant difference between
(CIs) were calculated. Heterogeneity was quantified with I - inflammation-specific biomarkers (amylase, necrosis,
2
statistics. edema, leukocyte infiltration) disappeared after 3 acute
Results: Based on the analysis of 1,515 patients from three episodes.
articles, SO increased overall mortality compared to non-SO Conclusion. Three or more attacks of AP with no
at short-, intermediate-, and long-term follow-up (RR=2.06, morphological changes of the pancreas should be nominated
95% CI: 1.28-3.33; RR=1.67, 95% CI: 1.10-2.51; and as early CP.
RR=2.08, 95% CI: 1.10-3.93, respectively) without significant
between-study heterogeneity for short- and intermediate- 58. ORAL MANIFESTATIONS ARE NOT INFREQUENT IN
2
term (I =0.0% for both) and considerable heterogeneity for PATIENTS WITH GASTROESOPHAGEAL REFLUX
2
long-term follow-up (I =81.1%). DISEASE (GERD)
Conclusions: Pre-transplant SO proved to be a risk factor Helle K. , Ollé G. , Bálint L. , Antal M. , Árok A. , Inczefi O. ,
1
2
2
1
1
1
after LT and associated with two times higher mortality at Róka R. , Rosztóczy A.
1
1
short and long-term follow-up. Since SO worsen the 1. SZTE SZAKK I. sz. Belgyógyászati Klinika; 2. SZTE FOK
prognosis of patients after LT, inclusion of body composition Konzerváló és Esztétikai Fogászati Tanszék
assessment before LT may help to plan a more individualised
nutritional treatment, physiotherapy, and postoperative care Introduction: The Montreal consensus defines dental
and may improve morbidity and mortality. erosion as an established extraesophageal complication of
GERD. In contrast, a little is known about the real prevalence
57. THE NEW DEFINITION OF EARLY CHRONIC of either this complication or other oral manifestations of the
PANCREATITIS disease. Furthermore, such data were not yet obtained in
3
4
4
1,2
1
Hegyi P. , Soós A. , Tóth E. , Ébert A. , Venglovecz V. , Hungary.
2
2
2
1
Márta K. , Mikó A. , Bajor J. , Sarlós P. , Vincze Á. , Halász Therefore, we aimed to collect data on the prevalence of
1,2
3
5
5
3
6
A. , Izbéki F. , Szepes Z. , Czakó L. , Kovács G. , Papp M. , different oral manifestations.
6
7
Dubravcsik Z. , Varga M. , Hamvas J. , Németh B. , Erőss Patients, methods: One-hundred and sixteen patients (M/F:
9
3
8
1,2
B. , Pécsi D. , Szentesi A. , Párniczky A. 1,10 , Hegyi P. 1,2,3 51/65, mean age: 54 (17-80) years) with typical symptoms of
1,2
1,3
1. Institute for Translational Medicine, Medical School, GERD were enrolled after detailed esophageal function
Szentágothai Research Centre, University of Pécs, Pécs, testing (upper gastrointestinal endoscopy, esophageal
Hungary; 2. Division of Gastroenterology, First Department manometry and 24-hour intraesophageal pH-impedance
of Medicine, Medical School, University of Pécs, Pécs, monitoring). Dental habits, typical and atypical reflux
Hungary; 3. First Department of Medicine, University of symptoms were assessed, then oral examinations were
Szeged, Szeged, Hungary; 4. Department of Pharmacology carried out. Based on the results of the evaluation two groups
and Pharmacotherapy, Szeged; 5. Szent György Teaching were formed: patients with GERD, and patients without
Hospital of County Fejér, Székesfehérvár, Hungary; 6. gastroesophageal reflux (= functional heartburn, FHB).
Department of Internal Medicine, Division of Results: Among our patients with GERD (66/116) the dental
Gastroenterology, University of Debrecen, Debrecen, erosions were significantly more common, than in patients
Hungary; 7. Bács-Kiskun County Hospital, Kecskemét, with FHB (21/66, 32% vs. 6/50, 12%; p<0.05). Furthermore,
Hungary; 8. Dr. Réthy Pál Hospital, Békéscsaba, Hungary; 9. we established significantly more and more severe
Peterfy Hospital and Trauma, Trauma Emergency Room, parodontological problems in patients with GERD group
Hungary; 10. Heim Pál National Institute of Pediatrics, (60/66, 90% vs. 30/50, 60%; p<0.05), with a lower number of
Budapest, Hungary teeth which did not reach the level of statistical significance
(18 vs. 21; p=0.09). On the other hand, patients with dental
Objective. Chronic pancreatitis (CP) is an end-stage disease erosions had longer history of heartburn and had more
with no specific therapy. We hypothesized that recurrent commonly regurgitation/vomiting.
acute pancreatitis (RAP) is an intermediate stage between Conclusion: In patients with GERD dental erosions and
acute pancreatitis (AP) and CP. parodontopathies are much more common, than in patients
Design. Prospectively collected international clinical dataset with FHB. Therefore, in patients with heartburn the earlier
of AP(n=1,349) and CP(n=318) and an experimental diagnosis of GERD may help to prevent the long term oral
pancreatitis model were used. 102 clinical and laboratory complications and subsequent prosthetic consequences.
biomarkers were compared across AP (non-CP), RAP (non-
CP), and CP groups. Concerning the experimental part of the 59. PARODONTOPATHY SEEMS TO PREDICT BETTER
THE PRESENCE OF GASTROESOPHAGEAL REFLUX
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54 Central European Journal of Gastroenterology and Hepatology
Volume 6, Supplementum 2 / November 2020