Page 61 - Magyar Gasztroenterológiai Társaság 2020. november 6–7. – ONLINE KONGRESSZUS

Előadáskivonatok / Abstracts

thrombosis is 6 times higher in IBD patients than healthy
people. Therefore we compared the expression of SerpinE1
thrombosis is 6 times higher in IBD patients than healthy Introduction: Acute liver failure is a potentially life-
people. Therefore we compared the expression of SerpinE1 Introduction: Acute liver failure is a potentially life-
in patients before and after therapy. Mucosal expression of
threatening condition, which can occur without underlying
liver disease. Liver support therapies can be applied as
SerpinE1 differed significantly in healthy subjects compared
in patients before and after therapy. Mucosal expression of threatening condition, which can occur without underlying a
bridging-to-transplantation or bridging-to-recovery; however,
to IBD patients with active disease (0 vs. 24.06pg/mg,
SerpinE1 differed significantly in healthy subjects compared liver disease. Liver support therapies can be applied as a
p=0.02). Mucosal expression of SerpinE1 showed
to IBD patients with active disease (0 vs. 24.06pg/mg, a bridging-to-transplantation or bridging-to-recovery; however,
results of clinical trials are controversial.
Aims: To compare liver support systems’ efficacy and safety
p=0.02). Mucosal expression of SerpinE1 showed a results of clinical trials are controversial.
remarkable decrease in patients who responded to the
remarkable decrease in patients who responded to the Aims: To compare liver support systems’ efficacy and safety
in a network meta-analysis in acute and hyperacute liver
therapy (p=0.06) compared to non-responders (p=0.15).
failure.
Moreover, mean value of mucosal SerpinE1 concentration
therapy (p=0.06) compared to non-responders (p=0.15). in a network meta-analysis in acute and hyperacute liver
Methods: We conducted search in 5 databases without any
Moreover, mean value of mucosal SerpinE1 concentration to failure.
did not differ significantly in healthy subjects compared
restrictions on October 4, 2019. Randomized controlled trials
responders (5.7 vs. 0 pg/mg, p=0.12).
did not differ significantly in healthy subjects compared to Methods: We conducted search in 5 databases without any
responders (5.7 vs. 0 pg/mg, p=0.12). that mucosal SeprinE1 restrictions on October 4, 2019. Randomized controlled trials
Conclusion: Our results suggest
were included comparing liver support therapies to standard
Conclusion: Our results suggest that mucosal SeprinE1 were included comparing liver support therapies to standard
expression reflects endoscopic activity of IBD, which could
medical therapy (SMT) in adults with liver failure. Data were
be a promising marker of disease activity and therapeutic
extracted to the study database; risk of bias was assessed
expression reflects endoscopic activity of IBD, which could medical therapy (SMT) in adults with liver failure. Data were
response.
be a promising marker of disease activity and therapeutic extracted to the study database; risk of bias was assessed
by Cochrane risk of bias tool. In-hospital mortality was the
primary outcome, the secondary outcomes were hepatic
response. by Cochrane risk of bias tool. In-hospital mortality was the

72. DIFFERENCES IN THE FREQUENCY OF CRC- primary outcome, the secondary outcomes were hepatic
encephalopathy and mortality-by-etiology. A Bayesian-
method was used to perform pairwise and network meta-
ASSOCIATED PATHOGEN VARIANTS IN COLORECTAL
72. DIFFERENCES IN THE FREQUENCY OF CRC- encephalopathy and mortality-by-etiology. A Bayesian-
ASSOCIATED PATHOGEN VARIANTS IN COLORECTAL method was used to perform pairwise and network meta-
analysis. All analyses were carried out under a random effect
ADENOMAS AND CANCERS FROM THE HUNGARIAN
POPULATION
model.
ADENOMAS AND CANCERS FROM THE HUNGARIAN analysis. All analyses were carried out under a random effect
1,2
3
3
Results: 11 randomized controlled trials were included.
Kalmár A. , G
1,2
POPULATION alamb O. , Pipek O. , Medgyes-Horváth A. , model.
3
1
1
SUCRA values indicate that BioLogic-DT® and MARS®
3 1
1,2
Szabó G. , Barták B. , Nagy Z. , Zsigrai S. , Szigeti K.
2
1,2
1
Kalmár A. , Galamb O. , Pipek O. , Medgyes-Horváth A. , , Results: 11 randomized controlled trials were included.
Szabó G. , Barták B. , Nagy Z. , Zsigrai S. , Szigeti K. , SUCRA values indicate that BioLogic-DT® and MARS®
(76% and 73%) are associated with the lowest mortality. In
11,2
Csabai I. , Tulassay Z. , Igaz P. , Molnár B.
1 1,2
1
1 1,2
2 3
non-paracetamol-poisoned patients BioLogic-DT®, charcoal
1. 2nd Department of Internal Medicine,
1,2
3
1,2
Csabai I. , Tulassay Z. , Igaz P. , Molnár B. Semmelweis (76% and 73%) are associated with the lowest mortality. In
1,2
University, Budapest; 2. Molecular Medicine Research Unit,
1. 2nd Department of Internal Medicine, Semmelweis non-paracetamol-poisoned patients BioLogic-DT®, charcoal to
hemoperfusion and MARS® may be equally efficient
University, Budapest; 2. Molecular Medicine Research Unit, hemoperfusion and MARS® may be equally efficient to
Hungarian Academy of Sciences, Budapest; 3. Department
decrease mortality (53%, 52% and 52%, respectively).
Considering hepatic encephalopathy, ELAD® may be the
Hungarian Academy of Sciences, Budapest; 3. Department decrease mortality (53%, 52% and 52%, respectively).
of Physics of Complex Systems, Eötvös Loránd University,
Budapest
of Physics of Complex Systems, Eötvös Loránd University, Considering hepatic encephalopathy, ELAD® may be the
most effective in reducing hepatic encephalopathy compared

to BioLogic-DT® or SMT (78%, 44% and 28%). However,
Budapest most effective in reducing hepatic encephalopathy compared
there were no statistically significant differences between the
Introduction: Colorectal cancer (CRC) has high incidence in to BioLogic-DT® or SMT (78%, 44% and 28%). However,
Introduction: Colorectal cancer (CRC) has high incidence in there were no statistically significant differences between the
Hungary.
interventions in any of the outcomes.
Hungary. aimed to perform whole exome sequencing on interventions in any of the outcomes. to be the best available
Conclusion: MARS® therapy seems
Aims: We
Aims: We aimed to perform whole exome sequencing on Conclusion: MARS® therapy seems to be the best available
option in reducing in-hospital mortality, although no
colorectal tissue samples in order to identify characteristic
statistically significant differences could be observed among
germline and somatic variants.
colorectal tissue samples in order to identify characteristic option in reducing in-hospital mortality, although no
the treatments. Further research is needed on currently
Methods: Genomic DNA was
germline and somatic variants. isolated from 27 adenomas, statistically significant differences could be observed among
Methods: Genomic DNA was isolated from 27 adenomas, the treatments. Further research is needed on currently
52 CRC, 18 healthy patients and from 2 colorectal cancer cell
available and new therapeutic modalities.

52 CRC, 18 healthy patients and from 2 colorectal cancer cell available and new therapeutic modalities.
lines. Exome enrichment was done with the Nextera DNA
lines. Exome enrichment was done with the Nextera DNA 74. EARLY PHASE OF CHRONIC PANCREATITIS:
Exome Kit and sequencing was performed using the
Exome Kit and sequencing was performed using the 74. EARLY PHASE OF CHRONIC PANCREATITIS:
NextSeq 500 Instrument. Germline and somatic variants
RESULTS OF THE FIRST 20 MONTHS OF THE
GOULASH-PLUS CLINICAL STUDY
NextSeq 500 Instrument. Germline and somatic variants RESULTS OF THE FIRST 20 MONTHS OF THE
were determined by Genome Analysis Toolkit (GATK)
including HaplotypeCaller and MuTect2 algorithms and were
2
Kató D. , Mikó A. , Lillik V. , Gajdán L.
were determined by Genome Analysis Toolkit (GATK) GOULASH-PLUS CLINICAL STUDY , Papp M. , Földi I. ,
1
3
1
1
3
including HaplotypeCaller and MuTect2 algorithms and were Kató D. , Mikó A. , Lillik V. , Gajdán L. , Papp M. , Földi I. , ,
1 4
1
1
Bódis B. , Faluhelyi N. , Sarlós P. , Vincze Á. , Szepes Z.
5
4
2
confirmed by ddPCR and in situ hybridization.
3 6
3
4
4
6
Results: Certain CRC-associated genes could be detected
5 8
confirmed by ddPCR and in situ hybridization. Bódis B. , Faluhelyi N. , Sarlós P. , Vincze Á. , Szepes Z. ,
6
1,9,10,11
Elsayed G. , Mosler P. , Erőss B. , Czakó L. , Hegyi P.
7
4
4
4
6
4
in a relatively lower [e.g. APC: 63,5%, TP53: 48,1%], or with
1. Institute for Translational Medicine, Szentágothai
8
Results: Certain CRC-associated genes could be detected Elsayed G. , Mosler P. , Erőss B. , Czakó L. , Hegyi P. 1,9,10,11
7
relatively higher mutation frequency [TTN: 48,1%, KRAS:
Research Centre, Medical School, University of Pécs,
in a relatively lower [e.g. APC: 63,5%, TP53: 48,1%], or with 1. Institute for Translational Medicine, Szentágothai
Hungary; 2. Szent György University Teaching Hospital
40,4%] compared to the TCGA database. Among the
relatively higher mutation frequency [TTN: 48,1%, KRAS: Research Centre, Medical School, University of Pécs, of
40,4%] compared to the TCGA database. Among the Hungary; 2. Szent György University Teaching Hospital of of
germline variants, MTHFR A1298C, MTR A2756G and
Fejér County, Székesfehérvár, Hungary; 3. Department
MTRR A66G were detected with a relatively higher frequency
Internal Medicine, Division of Gastroenterology, University of
germline variants, MTHFR A1298C, MTR A2756G and Fejér County, Székesfehérvár, Hungary; 3. Department of
Division
Debrecen,
Debrecen,
4.
Hungary;
in the Hungarian population compared to the worldwide
MTRR A66G were detected with a relatively higher frequency Internal Medicine, Division of Gastroenterology, University of of
4.
Gastroenterology, First
in the Hungarian population compared to the worldwide Debrecen, Debrecen, Department of Medicine, University
Hungary;
of
Division
statistics.
statistics. Gastroenterology, First Department of Medicine, University
Conclusion: Alterations in the frequencies of CRC-
of Pécs, Pécs, Hungary; 5. Department of Radiology,
associated somatic variants compared to the TCGA
University of Pécs, Pécs Hungary; 6. 1st Department
Conclusion: Alterations in the frequencies of CRC- of Pécs, Pécs, Hungary; 5. Department of Radiology, of
associated somatic variants compared to the TCGA University of Pécs, Pécs Hungary; 6. 1st Department of
database might contribute to the high CRC incidence
Medicine, University of Szeged, Szeged, Hungary; 7. Royal
8.
Bournemouth
database might contribute to the high CRC incidence Medicine, University of Szeged, Szeged, Hungary; 7. Royal
Hospital,
Kantonsspital
observed in the Hungarian population. Certain germline
England;
Kantonsspital
8.
observed in the Hungarian population. Certain germline Bournemouth Switzerland; 9. Hungarian Academy of
Graubünden,
England;
Hospital,
variants of the folate cycle genes observed with a relatively
Sciences, Momentum Gastroenterology Multidisciplinary
higher frequency in our cohort potentially have an effect on
variants of the folate cycle genes observed with a relatively Graubünden, Switzerland; 9. Hungarian Academy of
Research Group, University of Szeged, Szeged, Hungary;
higher frequency in our cohort potentially have an effect on Sciences, Momentum Gastroenterology Multidisciplinary
the DNA methylation regulation system that might be a link
the DNA methylation regulation system that might be a link Research Group, University of Szeged, Szeged, Hungary; of
between the genetic and epigenetic alterations of the CRC
10. Division of Translational Medicine, First Department
development.
Medicine, Medical School, University of Pécs, Pécs,
between the genetic and epigenetic alterations of the CRC 10. Division of Translational Medicine, First Department of
development. Medicine, Medical School, University of Pécs, Pécs,
Hungary; 11. on behalf of the Hungarian Pancreatic Study

73. LIVER SUPPORT THERAPIES IN ACUTE LIVER Hungary; 11. on behalf of the Hungarian Pancreatic Study
Group
73. LIVER SUPPORT THERAPIES IN ACUTE LIVER Group

FAILURE: A NETWORK META-ANALYSIS
FAILURE: A NETWORK META-ANALYSIS Z. , Párniczky Introduction: Acute pancreatitis (AP) is a severe
1
1
1,2
1
Kanjo A. , Ocskay K. , Gede N. , Szakács
1
1
4
1
4
Kanjo A. , Ocskay K. , Gede N. , Szakács Z. , Párniczky Introduction: Acute pancreatitis (AP) is a severe
1,2
inflammatory disease that can lead to irreversible
1
1 3
1,2
A. , Stange J. , Mitzner S. , Hegyi P. , Bobek I. , Molnár Z.
A. , Stange J. , Mitzner S. , Hegyi P. , Bobek I. , Molnár Z. inflammatory disease that can lead to irreversible
1. Institute for Translational Medicine, Medical School,
1,2
4
1
complications such as recurrent acute pancreatitis (RAP)
3
4
1
and chronic pancreatitis (CP). CP is often diagnosed in an
University of Pécs; 2. Heim Pál National Institute for
1. Institute for Translational Medicine, Medical School, complications such as recurrent acute pancreatitis (RAP)
advanced form, though it could be effectively managed at an
University of Pécs; 2. Heim Pál National Institute for of and chronic pancreatitis (CP). CP is often diagnosed in an
Pediatrics; 3. Dél-Pesti Centrum Hospital; 4. University
Pediatrics; 3. Dél-Pesti Centrum Hospital; 4. University of advanced form, though it could be effectively managed at an
Rostock
Rostock
59
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Central European Journal of Gastroenterology and Hepatology 59
Volume 6, Supplementum 2 / November 2020