Page 58 - Magyar Gasztroenterológiai Társaság 2020. november 6–7. – ONLINE KONGRESSZUS

Előadáskivonatok / Abstracts

alkalmaztuk, melyet egyszer, 20 mg/kg dózisban adtunk 8- Conclusion: The observed mortality data are consistent with
10 hetes hím C57BL/6 egereknek per os. A kontroll állatokat international indicators. By extending the registry, making it
a vegyület oldószerével (1% hidroxietilellulóz) kezeltük. Az nationwide, we will be able to provide comprehensive results.
indometacin által okozott enteropátiát 24 óra múlva
vizsgáltuk a vékonybélben található különböző gyulladásos 64. OUR EXPERIENCE OF THE ROLE OF
és antimikrobiális fehérjék mennyiségének mérésével, NASOGASTROSCOPE IN UPPER GASTROINTESTINAL
immunhisztokémiai módszerrel és Western blottal. Az LPA2 STENOSIS
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receptorok szerepének vizsgálatához egyrészt LPA2 Ilyés S. , Szalai L. , Bordás L. , Rácz B. , Crai S. , Vágó A. ,
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receptor génkiütött (KO) egereket használtunk, másrészt a Zsóri G. , Netye Z. , Fazekas I. , Gurzó Z. , Novák J.
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receptor agonistáját (DBIBB), melyet 1 és 10 mg/kg-os 1. Department of Gastroenterology, Kálmán Pándy Hospital,
dózisban adtunk vad típusú egereknek két alkalommal (24 Békés County Central Hospital, Gyula; 2. Endoscopic
órával és 30 perccel) az indometacin adása előtt. Laboratory, Kálmán Pándy Hospital, Békés County Central
Eredmények: 24 órával az indometacin adását követően a Hospital, Gyula
vad típusú egerekben enteropátia alakult ki, különböző
gyulladásos fehérjék (ciklooxigenáz-2, interleukin-1 beta, Introduction: It has been several decades since the first
myeloperoxidáz, pentraxin-3), valamint a szintén endoscope has appeared. The rigid gastroscope was first
immunsejtekből felszabaduló cathelicidin antimikrobiális replaced by flexible, then even thinner and more modern
fehérje emelkedett szöveti szintjével. LPA2 receptor KO types. Within this frame, we aim to present our own
egerekben ezen fehérjék expressziója szignifikánsan experience with the nasogastroscope, the thinnest tool
alacsonyabb volt a vad típusban mért szintekhez képest. Az currently available.
LPA2 receptor agonista DBIBB önmagában nem okozott Methods: In our Gastroenterology Department, we have the
bélgyulladást vad típusú egerekben, azonban dózisfüggően opportunity to perform nasogastroscopy since 2016. During
súlyosbította az indometacin által okozott enteropátiát. 2017–2018, we have performed this procedure on 20
Következtetések: Kísérleteinkkel elsőként igazoltuk, hogy patients due to gastrointestinal obstruction. The procedural
az LPA2 receptorok aktivációja súlyosbítja, míg génjük data of these patients were analyzed, and through 4 case
kiütése mérsékeli az NSAID-ok által okozott bélgyulladást reports we present the importance and the scope of potential
egerekben. Eredményeink alapján az LPA2 receptorok in the usage of nasogastroscope in upper and lower
lehetséges célpontok az NSAID-enteropátia kezelésében. gastrointestinal stenosis.
Támogatás: NKFI FK 124878, K 125174. Results: 20 patients (17 male, 3 female, mean age: 58.2
years) were involved in our research. In 19 cases the
63. A HIGH MORTALITY OF 21% IN 2 MONTHS IN THE examination was successful, but in one case the
HUNGARIAN GASTROINTESTINAL BLEEDING nasogastroscope did not reach the esophagus because of
REGISTRY- ANALYSIS OF THE FIRST 100 CASES the neoplastic process of the larynx. Percutaneous
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Hágendorn R. , Vörhendi N. , Berki D. , Csontos A. , Frim endoscopic gastrostomy (PEG) was implanted three times
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L. , Vincze A. , Szabó I. , Hegyi P. , Erőss B. with the help of nasogastroscope.
1. Institute for Translational Medicine, Medical School, Conclusions: We can conclude that the nasogastroscope is
University of Pécs, Pécs, Hungary; 2. Division of a vital element of the endoscopy lab. In upper and lower
Gastroenterology, First Department of Medicine, Medical gastrointestinal stenosis - when a conventional endoscope
School, University of Pécs, Pécs, Hungary fails to get through the stenosis - this ultra-thin device can be
used to examine the upper gastrointestinal tract safely, so we
Introduction: Gastrointestinal bleeding (GIB), one of the can get closer to making the diagnosis. Although the
most common causes of hospital admission in possibility of invasive interventions with this device is limited,
gastroenterology, has a reported 30 days mortality around 10 our experience highlights that PEG implantation – which is
percent. impossible with a conventional instrument – can be safely
Aims: To evaluate the mortality rate and describe the cause performed with nasogastroscopy.
of death of the study population.
Methods: The Hungarian Gastrointestinal Bleeding Registry 65. PREVALENCE OF CELIAC DISEASE IN CYSTIC
had received the ethical and biobank permission in August FIBROSIS: A META-ANALYSIS.
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2019. Between 07/10/2019 and 07/02/2020, 100 patients Imrei M. , Németh D. , Szakács Z. , Hegyi P. 1,2,3 , Kiss S. ,
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were enrolled. We analyzed the mortality rates in our cohort Alizadeh H. , Dembrovszky F. , Pázmány P. , Bajor J. ,
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during hospitalization and after gastroenterological emission. Párniczky A.
Results: 11 deaths (11%) occurred during hospitalization. Of 1. Institute for Translational Medicine, Medical School,
these, 2 (2%) were directly associated with haemorrhage University of Pécs, Pécs, Hungary; 2. First Department of
(variceal bleeding: 1, duodenal ulcer: 1). In 9 cases (9%), Medicine, University of Szeged, Szeged, Hungary; 3.
after successful treatment of the bleeding, deterioration from Division of Translational Medicine, First Department of
various comorbidities was reported as cause of death Medicine, Medical School, University of Pécs, Pécs,
(pneumonia: 2 (2 %), end stage of lung cancer: 1 (1%), Hungary; 4. Hungarian Academy of Sciences-University of
sepsis: 3 (3%), liver failure: 1 (1%) , heart failure: 1 (1%), end- Szeged, Translational Multidisciplinary Research Group,
stage colon cancer: 1 (1%). Following discharge from Szeged, Hungary; 5. Heim Pál National Institute of
gastroenterology, 10 deaths (10%) occured during follow-up. Pediatrics, Budapest, Hungary; 6. Division of Hematology,
Of these, 2 (2%) was caused direct by GIB (variceal bleeding: First Department of Medicine, Medical School, University of
1 (1%), gastric cancer: 1 (1%)). In 8 cases (8%) other causes Pécs, Pécs, Hungary; 7. Division of Gastroenterology, First
of death were found (tumor 3 (3%), pneumonia 1 (1%), Department of Medicine, Medical School, University of Pécs,
unknown 2 (2%), sepsis 2 (2%)). Within 30 days, mortality Pécs, Hungary; 8. Doctoral School of Clinical Medicine,
was seen in 15 patients (15%). Deaths between 30 and 60 University of Szeged
days were observed in 6 patients (6%). The mean age of our
patients at death was 73.1 years. Background and aim: Experimental studies provided
evidence on the potential role of the cystic fibrosis
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56 Central European Journal of Gastroenterology and Hepatology
Volume 6, Supplementum 2 / November 2020