Page 112 - A Magyar Szemorvostársaság 2023. évi kongresszusa - Tudományos program és előadáskivonatok

Data Extraction and Synthesis: Two authors independently extracted all data and evaluated
quality and applicability of eligible studies using the Quality Assessment of Diagnostic
Accuracy Studies 2 (QUADAS-2). Disagreements were resolved by a third author.

Main Outcomes and Measures: Sensitivity and specificity of the Amsler grid for detecting
neovascular AMD with comparators being either healthy controls or non-neovascular AMD
patients.

Results: Out of 523 records screened, 10 studies were included with a total of 1,890 eyes.
Sensitivity and specificity to diagnose neovascular AMD was 67% (95%CI: 51–79%) and 99%
(95%CI: 85–100%) when comparators were healthy controls, whereas it was 71% (95%CI:
60–80%) and 63% (95%CI: 49–51%) when controls were patients with non-neovascular AMD.
Overall, potential sources of bias were low across studies.

Conclusions and Relevance: Although the Amsler grid is easy and inexpensive to use for
detection of metamorphopsia, its sensitivity may be at levels typically not recommended for
monitoring. Coupling this with only moderate specificity to identify neovascular AMD in a
population at risk, typically such patients likely should be encouraged to undergo ophthalmic
examination regularly, regardless of any results of Amsler grid self-assessment.