Page 117 - A Magyar Szemorvostársaság 2023. évi kongresszusa - Tudományos program és előadáskivonatok

Results: A significant increase in nonspecific IgG levels in the AMD group was detected
compared to the control group (13.37 ± 6.65 vs. 9.44 ± 6.55 µg/ml; p=0.03). In 11 patients,
intraocular anti-aflibercept immunoglobulins could be detected (0.05 ± 0.01 µg/ml) which was
significantly higher than the limit of detection for anti-aflibercept (0.04 µg/ml; p=0.001). No
correlation was found between the number of injections or the type of CNV and the aqueous
level of anti-aflibercept (r=0.02; p=0.95).

Conclusion: According to our results, penetration of non-specific systemic antibodies through
the impaired blood-retinal barrier is higher in patients with neovascular AMD than in subjects
with an intact structural barrier. Evaluation of neutralizing antibodies to anti-VEGF agents in
the aqueous humour can lead us to understanding tachyphylaxis and changes in intraocular
immune mechanisms in AMD.