Page 41 - Magyar Gasztroenterológiai Társaság 2020. november 6–7. – ONLINE KONGRESSZUS

Előadáskivonatok / Abstracts

Conclusion: Fentanyl treatment diminished the severity of therapy to that of intravenous PPI therapy for bleeding peptic
necrotizing AP, but did not affect edematous AP in rats. ulcers. The primary outcome was 30-day mortality. Odds
Further investigations are needed to reveal the underlying ratios (OR) with 95% confidence intervals (CI) were
pathomechanisms. calculated for dichotomous outcomes, while weighted mean
differences (WMD) with CI were calculated for continuous
15. THE EVALUATION OF FUNCTIONAL outcomes in meta-analysis. The protocol of the study was
GASTROINTESTINAL SYMPTOMS IN PATIENTS WITH registered a priori onto PROSPERO.
PSYCHITRIC DISORDERS Results: A total of 13 RCT reported 1751 peptic ulcer
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Bálint L. , Helle K. , Ollé G. , Ilia K. , Felber M. , Rózsavölgyi patients, 881 and 870 of which were in the control and
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K. , Inczefi O. , Róka R. , Rosztóczy A. intervention groups, respectively. There were no statistically
1. SZTE SZAKK I. sz. Belgyógyászati Klinika; 2. Békés significant differences between treatments regarding 30-day
Megyei Központi Kórház, Pándy Kálmán Tagkórház, mortality (OR=0.72, CI, 0.29–1.76); 30-day rebleeding rate
Ideggondozó (OR, 0.91, CI, 0.59–1.38); length of hospital stay (WMD = -
0.34 days, CI: -1.17–0.49); transfusion requirements (WMD
Introduction: The association between psychiatric- (such as = -0.05 PRBC unit, CI: -0.28–0.18); need for surgery (OR =
anxiety and depression) and functional gastrointestinal (FGI) 0.91, CI: 0.40–2.07); further endoscopic therapy (OR = 1.04,
disorders had been reported earlier, however it had been CI: 0.56–1.93); and need for re-endoscopy (OR = 0.83, CI:
remained largely uninvestigated. 0.51–1.33). Heterogeneity was negligible in all analysis,
Therefore, the aim of our study was to collect data about the except for that on the length of hospitalization (I =81.2%,
2
prevalence of FGI symptoms among patients with psychiatric p<0.001).
disorders. Furthermore, we aimed to compare these to our Conclusion: Recent evidence suggests that the oral
previous findings among (n=2002) blood donor volunteers. administration of PPIs is not worse than the currently
Methods: One-hundred and sixty-three (M/F: 46/117, mean recommended intravenous PPI treatment in bleeding peptic
age: 57 (19-85) years) with different psychiatric disorders ulcers after endoscopic assessment, warranting guideline
were enrolled. Patients were asked to complete a revision.
standardized questionnaire about their FGI symptoms and
quality of life (QoL). 17. PRESENTING SYMPTOMS AND LENGTH OF
Results: Among the studied patients, 21 (13%) had anxiety, HOSPITAL STAY IN GASTROINTESTINAL BLEEDING -
31 (19%) had depression, 95 (58%) had both and 16 (10%) ANALYSIS OF 100 GASTROINTESTINAL BLEEDING
had other disorders. Due to heterogenicity of latter group, CASES FROM A PROSPECTIVE COHORT
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these patients were excluded. The results showed that Csontos A. , Berki D. , Frim L. , Vörhendi N. , Vincze A. ,
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patients with depression±anxiety were older, had higher Szabó I. , Hegyi P. , Erőss B. , Hágendorn R.
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1
body mass index and worse QoL than those with anxiety 1. Institute for Translational Medicine, Medical School,
alone. Globus sensation and reflux related symptoms were University of Pécs, Pécs, Hungary; 2. Division of
more common in patients with depression (±anxiety). The Gastroenterology, First Department of Medicine, Medical
further FGI symptoms had similar prevalence in all groups. School, University of Pécs, Pécs, Hungary
Compared to blood donor volunteers all studied symptoms
were significantly more prevalent in patients with psychiatric Introduction: Gastrointestinal bleeding (GIB) is one of the
disorders. Interestingly, the prevalence of IBS was only most common causes of hospitalization, with various
halved by the Rome IV criteria compared to the Rome III symptoms and etiology.
(3.4% vs. 6.1%), while it had been decreased to one tenth in Aims: We aimed to give a descriptive analysis of patients
blood donor volunteers. from our prospective registry with a focus on symptoms and
Conclusion: FGI symptoms are more prevalent in patients etiology.
with anxiety±depression, than in blood donor volunteers. Methods: From 07/10/2019 to 07/02/2020, 100 patients
Globus and gastroesophageal reflux related esophageal consented to participate in the Hungarian Gastrointestinal
symptoms occurred more frequently among patients with Bleeding Registry. Data on gender, age, presenting
depression. symptoms, etiology, and length of hospital stay of GIB were
collected. We calculated means, standard deviation, and
16. COMPARISON OF ORAL VERSUS INTRAVENOUS percentage of each.
PROTON PUMP INHIBITORS FOR BLEEDING PEPTIC Results: Mean age in all patients, variceal-, non-variceal
ULCERS: A SYSTEMATIC REVIEW AND META- upper-, lower-, iatrogenic- and unidentified GIB groups was
ANALYSIS 70.0±12.7, 64.7±9.4, 69.5±13.2, 75.0±10.7, 66.8±11.6,
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Csiki E. , Hanna S. , Bálint E. , Hanák L. , Szakács Z. , 69.9±19.4 years, and 55.0%, 73.3%, 64.4%, 40.9%, 46.2%,
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Szabolcs K. , Vörhendi N. , Pécsi D. , Hegyi E. , Hegyi P. 25.0% of patients were male, respectively. Hematemesis
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1. Pécsi Tudományegyetem, Transzlációs Medicina Intézet; occured in 22/100 (22.0%), 9/15 (60.0%), 12/45 (26.7%),
MOGYE, Maros Megyei Klinikai Kórház; 2. Pécsi 0/22 (0.0%), 2/13 (15.4%), 1/8 (12.5%) of cases,
Tudományegyetem, Transzlációs Medicina Intézet; 3. respectively. Melena was the presenting symptom in 37/100
MOGYE; 4. Pécsi Tudományegyetem, Klinikai Központ I.sz. (37.0%), 8/15 (53.3%), 23/45 (51.1%), 3/22 (13.6%), 2/13
Belgyógyászati Klinika, Gasztroenterológiai Tanszék (15.4%), 2/8 (25.0%) of cases. Hematochezia was the first
sign in 42/100 (42.0%), 5/15 (33.3%), 10/45 (22.2%), 19/22
Introduction: Current guidelines recommend intravenous (86.4%), 5/13 (38.5%), 4/8 (50.0%) of cases respecively.
proton pump inhibitor therapy in peptic ulcer bleeding. There was no overt symptom of bleeding in 14/100 (14.0%),
Aims: We aimed to compare the efficacy of oral to 0/15 (0.0%), 7/45 (15.6%), 2/22 (9.1%), 4/13 (30.8%), 1/8
intravenous administration of proton pump inhibitors (PPI) in (12.5%) of cases, respectively. Mean length of
peptic ulcer bleeding. hospitalization was 7.4±4.8, 8.5±6, 7.8±5.1, 7.2±2.9, 6.9±6.0,
Methods: We performed a systematic search in PubMed, 5.3±1.4 days, respectively.
Cochrane, Embase, Scopus databases for randomized Conclusion: Here, we demonstrate that accurate data is
controlled trials which compared the outcomes of oral PPI collected in our registry. In future analyses, we will use it to
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Central European Journal of Gastroenterology and Hepatology 39
Volume 6, Supplementum 2 / November 2020