Page 36 - Magyar Gasztroenterológiai Társaság 2020. november 6–7. – ONLINE KONGRESSZUS

Előadáskivonatok / Abstracts

Előadások és poszterek összefoglalói

1. CORRELATIONS OF THE QUALITY OF LIFE AND (CeD); however, dietary adherence is difficult to be
FUNCTIONAL CONDITION QUESTIONNARIES WITH estimated: there is a need for the development of objective
CLINICAL AND BIOCHEMICAL PARAMETERS IN IBD assessment tools.
PATIENTS Aims: This study aims to compare multiple methods used to
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Bacsur P. , Szántó K. , Orosz R. , Gera I. , Nyári T. , Rutka estimate dietary adherence including a novel technology,
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M. , Bor R. , Fábián A. , Resál T. , Huszka L. , Szepes Z. , urine gluten immunogenic peptide (urine-GIP) detection.
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Nagy F. , Molnár T. , Farkas K. Methods: Dietary adherence of CeD patients on GFD at
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1. 1st Department of Medicine, University of Szeged; 2. least for 1 year was rated by an expert dietician between 1
Institute of Informatics, University of Szeged; 3. Department (normal diet) and 10 (perfect GFD). We used the
of Medical Physics and Informatics, University of Szeged Gastrointestinal Symptoms Rating Scale to assess
symptoms along 15 domains and a point-of-care-test to
Introduction: Inflammatory bowel diseases (IBD, Crohn’s detect urine-GIP from mid-stream urine. Besides, we
disease [CD], ulcerative colitis [UC]) are chronic, relapsing measured the level of tissue transglutaminase antibody
conditions of the gastrointestinal tract that affect every aspect (TGA-IgA and -IgG) and anti-endomysial antibody (EMA-IgA)
of the affected individual's life. In the last decades with total IgA levels to exclude IgA-deficiency. In statistical
management of IBD patients focused on the treat to target analysis, we calculated area under the curve (AUC),
(T2T) approach. Good quality of life (QoL) could also be an sensitivity (Se) and specificity (Sp).
important target next to the clinical, endoscopic, and Results: A total of 47 CeD patients were included. AUC for
hystological remission. dietary interview vs TGA-IgA was 0.789±0.093 (Se: 89%, Sp:
Aims: We aimed to assess the correlation between QoL self- 50%, cut-off: 9 points). When seropositivity (for at least one
questionnaries, clinical activity and objective activity antibody) and urine-GIP were compared to dietary interview,
markers. AUCs were 0.639±0.105 and 0.838±0.074, respectively.
Methods: Our prospective study took place at the 1 Symptom scores did not correlate with the dietary interview
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Department of Medicine, University of Szeged. IBD patients and serology but correlated moderately with urine-GIP levels
between ages of 18-65 years on maintenance anti-TNF-α (AUC: 0.771±0.093).
therapy were enrolled. Each patient signed a written Conclusion: Although literature data imply that urine-GIP
informed consent about the study. The follow up period was detection has excellent diagnostic performance in revealing
6 months and visits were scheduled in every 2 months. At dietary transgressions, our study failed to reproduce these.
each visit we assessed clinical activity scores (partial Mayo We must admit; however, that our sample size limits the
[pMayo] and Crohn’s Disease Activity Index [CDAI]) and robustness of the conclusions.
obtained self-filling questionnaries (IBD disk, Patient
Reported Outcome-2 [PRO2], Short Inflammatory Bowel 3. A TELJES INTRAVÉNÁS ANESZTÉZIA HELYE
Disease Questionnaire [SIBDQ], EQ-5D-3L, Visual Analog ENDOSZKÓPOS GYAKORLATUNKBAN. 1 ÉVES
Scale [VAS]) and recorded faecal calprotectin and C-reactive BETEGANYAG.
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protein levels (CRP). Balog I. , Magyarosi D. , Tóth L. , Sepsi B. , Pécsi D. , Kokas
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Results: Data of 50 IBD patients have been analyzed in the M. , Pécsi G.
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study. Significant differences were shown regarding to the 1. Karolina Kórház és Rendelőintézet
four visits’ IBD disk and SIBDQ values. We did not find any
difference between the mean values of the four visits as per Introduction: Az aneszteziológiai team által biztosított teljes
the PRO2, VAS, CDAI, CRP and calprotectin values. PRO2 intravénás anesztézia (TIVA) fájdalom nélkül elvégezhető
had a strong positive correlation with clinical activity indices endoscopos beavatkozásokra ad lehetőséget. Az így
(p<0.01) and with the CRP levels (p = 0.002). We found elvégzett vizsgálatok mennyisége évről évre emelkedő
significant correlations between the self-filling tendenciát mutat. A TIVA az endoscopia sikerét növeli, de
questionnaires. SIBDQ (CDAI, p = 0.003) and VAS (CDAI komplikációkkal is járhat.
and pMayo, p<0.01) values had a negative, IBD disk (pMayo, Aims: 2019-ben TIVA-ban végzett endoscopos
p = 0.019, CDAI, p = 0.004) had a positive correlation with beavatkozásaink retrospektív felmérése, különös tekintettel
the clinical activity indices. There was no correlation between a TIVA-ban végzett diagnosztikus és terápiás endoscopiák
the IBD disk score and the CRP or calprotectin. eredményeire, szövődményeire.
Conclusion: These questionnaries had correlations with the Methods: előzetes belgyógyászati és aneszteziológiai
clinical activity indices, but they did not correlate with szakorvosi vizsgálat, TIVA személyi és tárgyi feltételeinek
objective biological markers. Thus, these self-filling biztosítása, midazolam – fentanyl – propofol alapú
questionnaires are useful to present patients’ subjective anesztézia, perioperatív (EKG, RR, pulzoxymetria) szoros
quality of life and their functional condition, however did not obszerváció.
substitute regular medical and laboratory follow-up. Results: Egy év alatt összesen 3213 endoscopos
vizsgálatot végeztünk. TIVA-ban 213 betegnél összesen 287
2. FIRST EXPERIENCE WITH URINE GLUTEN vizsgálat történt (78 gastroscopia, 209 colonoscopia), mely
IMMUNOGENIC PEPTIDE DETECTION IN COELIAC az összes vizsgálatunk 8,89%-a. 62 férfi és 151 nő betegünk
DISEASE: A DIAGNOSTIC TEST ACCURACY STUDY volt, átlagéletkoruk 58,2 év (15-84) volt. 92 esetben
Bajor J. , Mester L. , Nagy M. , Farkas N. , Szakács Z. végeztünk endoscopos polypectomiát. Az anesztézia
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1. Division of Gastroenterology, First Department of indikációja leggyakrabban a félelem volt (korábbi endoscopia
Medicine, Medical School, University of Pécs, Pécs, okozta félelem: 58, primer félelem: 46), ezt követte a korábbi
Hungary; 2. Institute for Translational Medicine, Medical hasi műtét (48 eset), a bonyolult szituációjú endoscopia (43
School, University of Pécs, Pécs, Hungary; 3. Institute of eset), illetve a korábbi sikertelen endoscopia (18 eset). Totál
Bioanalysis, Medical School, University of Pécs, Pécs, colonoscopia 96,1 % volt (7 esetben aboralis stenosis, 1
Hungary esetben kritikus bradycardia miatt nem volt komplett a
colonoscopia). Endoscopos szövődmény nem volt, 1
Introduction: Strict gluten-free diet (GFD) is the only esetben altatás során EKG monitorozás közben
evidence-based treatment for patients with coeliac disease gyógyszeres kezelésre jól reagáló bradycardia volt
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34 Central European Journal of Gastroenterology and Hepatology
Volume 6, Supplementum 2 / November 2020