Page 76 - Magyar Gasztroenterológiai Társaság 2020. november 6–7. – ONLINE KONGRESSZUS

Előadáskivonatok / Abstracts

Budapest, Hungary; 4. Division of Translational Medicine, incidence of ESC (slope= -0.879, R = 0.535, p=0.001), while
2
First Department of Medicine, Medical School, University of the incidence of EAC and OPEM remained stable (slopes= -
2
Pécs, Pécs, Hungary; 5. First Department of Medicine, 0.107, -0.073; R =0.0398, 0.0845; p values: 0.45, 0.27). In
University of Szeged, Szeged, Hungary contrast, the incidence of cardia cancers increased during
2
the last 5 years (15-years-slope=0.25, R = 0.205, p=0.078,
2
Introduction: Alcohol-induced acute recurrent pancreatitis vs. 5-years-slope=1.43, R = 0,788, p<0.02).
(ARP) is a preventable and potentially chronic condition, Conclusions: The results obtained in South-East Hungarian
which significantly lowers quality of life. Both alcohol and subjects support those previous observations as the
tobacco abuse are independent risk factors for ARP and incidence of ESC decreases. In contrast, the increase of EAC
chronic pancreatitis. Due to the lack of evidence current incidence was not observed, only the cardia cancers became
guidelines on the management of pancreatitis are failed to more frequent.
give recommendation how to prevent ARP.
Aims: The ‘REAPPEAR A’ trial examines the effect of a 110. FLEXIBLE ENDOSCOPIC TREATMENT FOR
repeated, combined brief intervention on alcohol and ZENKER’S DIVERTICULUM: RESULTS OF OUR 44
smoking cessation on the recurrence of alcohol-induced ARP CONVENTIONAL INTERVENTIONS.
1
compared to a one-time combined intervention in a Orbán-Szilágyi Á. , Bakucz T. , Gyökeres T.
1
1
randomized, parallel group setting. 1. MH EK Honvédkórház
Methods: Estimated sample size is 124 patients/group
without dropouts. 18-65-year-old patients with alcoholic ARP Flexible endoscopic myotomy (FEM) of the cricopharyngeal
will be screened for eligibility. Other etiologies and chronic muscle is a widely used technique in the treatment of
pancreatitis will be ruled out. The intervention will be symptomatic Zenker’s diverticulum. It is considered to be
provided by a specially trained nurse in approximately 30 safe and effective. Nowadays a new endoscopic technique
minutes. All enrolled patients will receive the baseline using submucosal tunneling method (Z-POEM) has been
intervention before discharge. Patients will have introduced. Until now, no clear advantage of this new
appointments at months 3,6,9,12 and 18, where everyone technique has been confirmed. We retrospectively analyzed
will undergo routine laboratory testing and the repeated our experiences with conventional FEM. 35 patients with
intervention will be provided to the selected patients. symptomatic Zenker’s diverticulum were treated with FEM
Socioeconomic status, quality of life, alcohol consumption and 44 myotomies were performed from September 2012
and smoking habits will be assessed by questionnaires at until November 2019. 34 patients were followed (mean 15
every visit and samples will be collected for later biomarker months), 1 patient was lost to follow-up. Clinical success at 1
measurements. The primary endpoint is all-cause recurrence month was 91.1% (31/34). 3 patients remained symptomatic,
of pancreatitis and the cost-effectiveness of the intervention one of them was treated with re-myotomy and became
program will be evaluated. Patients will be enrolled in a symptom-free, another two patients refused further
prospective cohort, the REAPPEAR B concomitantly. interventions. Over the long term period, 25/31 patients
Conclusion: The objective of this study is to explore the remained symptom-free after one myotomy. 5/31 patients
efficacy of a brief intervention program in alcoholic ARP and required one further myotomy and 1 patient had to undergo
provide guidance for prevention. 2 more sessions of myotomies due to recurrence of
symptoms. The overall clinical success was 91.1% (31/34).
109. THE INCIDENCE OF ESOPHAGEAL We observed pneumomediastinum in one patient that was
ADENOCARCINOMA (EAC) IS NOT INCREASING IN treated conservatively successfully. Intraprocedural bleeding
SOUTH-EAST HUNGARY has occurred in (5/44) cases, in all of them the bleeding was
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1
1
1
3
Ollé G. , Helle K. , Bálint L. , Oláh J. , Lázár G. , Tiszlavicz successfully stopped during intervention. In one of them,
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L. , Vasas B. , Inczefi O. , Róka R. , Rosztóczy A. early recurrent massive bleeding required surgery. The
1
1
1
1. SZTE SZAKK I. sz. Belgyógyászati Klinika; 2. SZTE overall rate of significant complications was 4.5% (2/44), and
SZAKK Patológia Intézet; 3. SZTE SZAKK Sebészeti Klinika; there was no procedure-related mortality.
4. SZTE SZAKK Onkoterápiás Klinika
111. MRNA EXPRESSION AND SPLICE VARIANT
Introduction: Esophageal cancer is the 9th most common CHANGES IN THE COLORECTAL ADENOMA-
cancer and the 6th most common cause of cancer deaths CARCINOMA SEQUENCE
1
worldwide. While the incidence of esophageal squamous cell Papp M. , Kalmár A. , Tulassay Z. , Igaz P. , Molnár B.
1,2
1,2
1,2
1,2
cancer (ESC) is decreasing during the last three decades, 1. 2nd Department of Internal Medicine, Semmelweis
adenocarcinoma shows an opposite tendency. These University, Budapest; 2. Molecular Medicine Research Unit,
changes are most pronounced in the developed western Hungarian Academy of Science, Budapest
countries, while little is known about Central Europe. Introduction: Genomic level differentiation of healthy normal
Our aimed to collect data about the incidence of different colon, adenoma and colorectal cancer (CRC) samples are
types of esophageal cancers in South-East Hungary. essential to recognize patterns which help to develop
Methods: A retrospective analysis of the medical data of diagnostic and prognostic biomarkers.
patients with esophageal or cardia cancers from the last 15 Aims: We aimed to characterize splice variant differences
years (2004-2019) was carried out at the Department of along the development of CRC formation.
Pathology of the Albert Szent-Györgyi Clinical Centre in Methods: Expression profile of the samples was obtained
Szeged. using the Affymetrix Human Transcriptome Array 2.0 (HTA
Results: Overall 451 patients (M/F: 369/82, mean age: 69 2.0) microarray platform. 20 samples were analyzed in each
(28-103) years) were identified according to the enrollment groups (healthy colon, adenoma and CRC tissue samples).
criteria during the studied 15-years’ period. 294 of them Analysis of the arrays was done using the Transcriptome
(65%) had ESC, 77 (17%) EAC, 58 (13%) cardia cancer and Analysis Console (TAC) 4.0 (Affymetrix). We’ve determined
22 (5%) other primary esophageal malignancies (OPEM). the difference between sample expressions and searched for
The total number of esophageal cancers decreased possible exon events. Possible protein-protein interactions
2
significantly (slope= -0.81, R =0.387, p=0.01), such as the influenced by the expressional profiles of the healthy and
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74 Central European Journal of Gastroenterology and Hepatology
Volume 6, Supplementum 2 / November 2020