Page 49 - Magyar Gasztroenterológiai Társaság 2020. november 6–7. – ONLINE KONGRESSZUS

Előadáskivonatok / Abstracts

COMPLICATIONS OF ACUTE PANCREATITIS: A Fűr G. , Kiss L. , Bálint E. , Kormányos E. , Balla Z. , Czira
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PROSPECTIVE COHORT-ANALYSIS OF 1432 CASES B. , Venglovecz V. , Pallagi P. , Maléth J. , Hegyi P. ,
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Földi M. 1,2,3 , Kiss S. 1,2,3 , Gede N. , Vincze Á. , Bajor J. , Rakonczay Z.
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Szabó I. , Izbéki F. , Gervain J. , Hamvas J. , Vitális Z. , 1. Department of Pathophysiology, University of Szeged,
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Fehér E. , Crai S. , Sallinen V. , Ramirez Moldando E. , Szeged, Hungary; 2. Department of Pharmacology and
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Meckzer Á. , Varjú P. , Poropat G. , Stimac D. , Faluhegyi Pharmacotherapy, University of Szeged, Szeged, Hungary;
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N. , Miseta A. , Nagy T. , Vereczkei A. , Márton Z. , 3. First Department of Medicine, University of Szeged,
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Hegyi P. , Hegyi P. 2,3,6 , Párniczky A. 3,17 , Szentesi A. Szeged, Hungary; 4. MTA-SZTE Momentum Translational
1. Doctoral School of Clinical Medicine, University of Szeged, Gastroenterology Research Group, University of Szeged,
Szeged, Hungary; 2. First Department of Internal Medicine, Szeged, Hungary; 5. Institute for Translational Medicine,
University of Szeged, Szeged, Hungary; 3. Institute for University of Pécs, Pécs, Hungary
Translational Medicine, Medical School, University of Pécs,
Pécs, Hungary; 4. Devision of Gastroenterology, First Introduction: Cystic fibrosis transmembrane conductance
Department of Medicine, Medical School, University of Pécs, regulator (CFTR) and SLC26A6 anion exchanger have
Pécs, Hungary; 5. Szent György University Teaching essential roles in pancreatic ductal bicarbonate secretion.
Hospital of Fejér County, Székesfehérvár, Hungary; 6. Loss of CFTR function can trigger acute pancreatitis (AP)
Devision of Translational Medicine, First Department of and can also exacerbate disease severity. However, it is
Medicine, Medical School, University of Pécs, Pécs, unclear how AP affects ductal transporters.
Hungary; 7. Peterfy Hospital, Budapest, Hungary; 8. Aims: To investigate the expression and activities of CFTR
Department of Internal Medicine, Division of and SLC26A6 during AP and the effect of CFTR corrector
Gastroenterology, University of Debrecen, Debrecen, VX-661 on the severity of AP.
Hungary; 9. Pándy Kálmán Hospital of Békés County, Gyula, Methods: FVB/n mice were administered 6-10
Hungary; 10. Department of Transplantation and Liver intraperitoneal injections of 50μg/kg caerulein to induce AP.
Surgery, Helsinki University Hospital and University of Animals were sacrificed 0-72h after the first injection. A group
Helsinki, Helsinki, Finland; 11. General Surgery, Consorci of mice were pre-treated with 5 daily intraperitoneal injections
Sanitari del Garrof, Sant Pere de Ribes, Spain; 12. Croatia, of 2mg/kg VX-661. AP severity was evaluated by laboratory
Rijeka, Clinical Hospital Center Rijeka, Croatia; 13. and histological parameters. CFTR mRNA expression was
Department of Radiology, Medical School, University of measured by RT-qPCR. CFTR, SLC26A6 and cytokeratin-19
Pécs, Pécs, Hungary; 14. Department of Laboratory protein expressions were identified by
Medicine, Medical School, University of Pécs, Pécs, immunohistochemistry. Apical bicarbonate secretion was
Hungary; 15. Department of Surgery, Medical School, examined by intracellular pH measurement on
University of Pécs, Pécs, Hungary; 16. First Department of microdissected interlobular ducts.
Medicine, Medical School, University of Pécs, Pécs, Results: AP was the most severe between 12-24h. CFTR
Hungary; 17. Heim Pál National Institute of Pediatrics, mRNA expression was significantly increased at 24-48h.
Budapest, Hungary Staining morphology of CFTR protein was disturbed between
6-24h and started to recover from 48h. Intracellular pH
Introduction: Pain is the most common symptom in acute measurements revealed decreased bicarbonate secretion at
pancreatitis (AP), and is part of the diagnostic criteria. 12h compared to the control. Pre-treatment with VX-661
Aims: Since its clinical characteristics in AP have not been significantly reduced the extent of pancreatic necrosis,
detailed in the literature, we aimed to characterize acute oedema, and vacuolisation.
abdominal pain in AP. Conclusion: Caerulein-treatment markedly increased AP
Methods: The Hungarian Pancreatic Study Group (HPSG) severity and pancreatic CFTR mRNA expression, disturbed
has prospectively collected multicenter clinical data of 1435 the morphology of CFTR staining and decreased bicarbonate
adult AP patients between 2012 and 2017. The pain was secretion (ie. activity of transporters) at early time points.
characterized by (i) its intensity (Visual Analog Scale; 0–10), Importantly, treatment with ductal CFTR corrector decreased
(ii) duration prior to admission (hours), (iii) localization (9 AP severity.
regions of the abdomen), and (iv) type (sharp, dull, Acknowledgements: NKFIH, GINOP and EFOP.
cramping). Associations between the pain categories and
outcome parameters were investigated 40. WHEN THE SOLUTION IS IN THE HAND OF
Results: 97.3% of patients (n=1394) had pain on admission. SURGEON
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It was mostly severe (VAS 7–10: 70%, n=511), cramping Gaál A. , Tóth D. , Rokszin T. , Szólics A. , Fülöp F. , Varga
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(61%, n=705), and epigastric (48%, n=687). Severe pain was M.
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associated with a more severe disease course (p<0.05); 1. 2nd Department of Gastroenterology, Békés Country
however, it was not associated with a higher rate of mortality Central Hospital, Békéscsaba,; 2. Division of Surgery,
(p=0.826). Sharp pain was associated with AP severity Teaching Hospital of Country Borsod-Abaúj-Zemplén,
(OR=2.481 95% CI: 1.550-3.969), mortality (OR=2.263, 95% Miskolc,; 3. Division of Vascular Surgery, Békés Country
CI: 1.199–4.059), systemic complications (OR=2.263, 95% Central Hospital, Gyula,; 4. Division of Radiology, Békés
CI: 1.550–3.970) and new-onset diabetes (2.7% vs. 9.3%; Country Central Hospital, Gyula,
p<0.001). Longstanding pain (>72 h) on admission was not
associated with worse outcomes; however, it was associated Background: Median arcuate ligament syndrome (MALS) is
with milder (p<0.001) and rather dull pain (p<0.05), localized a rare condition in which the median arcuate ligament of the
in the right abdomen (p<0.005). diaphragm causes a respiratory-dependent compression of
Conclusion: The severity and sharpness of pain as patients the celiac trunk and leads to chronic postprandial abdominal
reported data on admission are strongly associated with the angina, recurrent nausea, vomitus and weight loss.
severity of AP, therefore, these patients should receive more Incidence of MALS is 2/100.000 with a female
attention by healthcare professionals. predominance.
39. THE CFTR CORRECTOR VX-661 AS A THERAPEUTIC Case report: We started the further examination of a 68-
OPTION IN EXPERIMENTAL ACUTE PANCREATITIS years old smoking woman who presented with thoracic and
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Central European Journal of Gastroenterology and Hepatology 47
Volume 6, Supplementum 2 / November 2020