Page 84 - Magyar Gasztroenterológiai Társaság 2020. november 6–7. – ONLINE KONGRESSZUS

Előadáskivonatok / Abstracts

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date of diagnosis, sex, diagnostic histology and tissue Szakó L. , Németh D. , Farkas N. , Kiss S. , Dömötör R. ,
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transglutaminase antibody (IgA) positivity at diagnosis, as Engh M. , Hegyi P. , Papp A. , Erőss B.
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covariates. 1. Institute for Translational Medicina, Medical School,
Results: A total of 747 CeD patients were included, 287 of University of Pécs; 2. Department of Surgery, Medical
which (38.4%) had classical phenotype. ATD and any AI School, University of Pécs; 3. Doctoral School of Clinical
were diagnosed in 15.8 and 31.4%, respectively. Male sex Medicine, University of Szeged
and classical phenotype were independently associated with
a lower frequency of ATD (OR=0.359, CI: 0.94-0.664, Introduction: Minimally invasive surgical techniques are
p=0.001 and OR=0.534, CI: 0.323-0.883, p=0.015; becoming predominant in all fields of surgery, including
respectively), as well as AIs. Although patients with classical oesophageal surgery. Several meta-analyses tried to
phenotype developed MTs more often, the difference was compare minimally invasive modalities with open techniques,
not statistically significant (4.9% vs 2.2%, OR=1.433, CI: including all types of comparative studies with significant
0.583-3.521, p=0.433). limitations.
Conclusion: The clinical phenotype predicts ATD and any Aims: Our goal is to compare all surgical modalities to each
AI but not MTs in CeD. other from results of randomized controlled trials, thus
providing objective evidence and a ranking of the different
131. BASELINE CHARACTERISTICS OF THE 27 techniques regarding survival, complication rate, operation
PARTICIPANTS ENROLLED IN THE ESOPHAGEAL time, hospital stay, and blood loss.
CANCER REGISTRY Methods: We conducted a systematic search of the
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Szakó L. , Tinusz B. , Csiki E. , Papp A. , Faluhelyi N. , PubMed, Embase, and Cochrane databases to identify
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Gombos K. , Hegedűs I. , Solt J. , Csikós Á. , Bellyei S. , relevant studies and performed a network meta-analysis
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Hegyi P. , Erőss B. (NMA). We used the random effect model. To ensure the
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1. University Of Pécs, Medical School, Institute For interpretability of the NMA results, we will present the
Translational Medicine; 2. Department of Surgery, Medical geometry of the network, the results with probabilistic
School, University of Pécs; 3. Institute of Pathology, Medical statements, and estimates of interventions’ effects along with
School, University of Pécs; 4. Department of their corresponding 95 % credible interval (CI), as well as
Gastroenterology, Medical School, University of Pécs; 5. forest plots. For ranking the interventions, we chose to use
Institute of Oncology and Oncotherapy, Medical School, the surface under the cumulative ranking (SUCRA) curve,
University of Pécs; 6. Department of Radiology, Medical which provides a numerical summary of the rank distribution
School, University of Pécs; 7. Department of Primary Health of each treatment.
Care, Medical School, University of Pécs; 8. Institute of Results: We included 12 studies in our analysis. A significant
Laboratory Medicine, Medical School, University of Pécs difference was found considering pulmonary infection, which
favored the laparoscopic intervention compared to
Introduction: There is a lack of epidemiological data on transthoracic surgery (risk ratio 0.49, 95% credible interval
esophageal cancer in Hungary, which necessitates a 0.23 to 0.99). Operation time was significantly shorter for
registry. transhiatal approach compared to transthoracic surgery
Aims: We aim to present the results of the analysis of the (mean difference -85 minutes, 95% credible interval -150 to
first 27 enrolled participants of the Esophageal Cancer -29), hybrid intervention (mean difference -98 minutes, 95%
Registry. credible interval -190 to -9.4), laparoscopic technique (mean
Methods: From March 2019 to 29 February 2020, the data difference -130 minutes, 95% credible interval -210 to -50),
of every enrolled participant were analyzed using simple and robot-assisted esophagectomy (mean difference -150
descriptive statistics. We extracted the data from the written minutes, 95% credible interval -240 to -53). Other
data collection forms to a preconceived Excel sheet. comparisons did not yield significant differences.
Results: We enrolled 27 participants in one year to the Conclusion: While individual studies suggest the superiority
Esophageal Cancer Registry. Nine participants were not of the minimally invasive techniques regarding multiple
enrolled since they did not give consent (2 participants), did outcomes, the summarized evidence is only conclusive
not show up (1 patient), were already under treatment (3 considering the complication rate and operation time.
participants), died before giving consent (1 patient), and Although the tendency suggests that minimally invasive
because of a language barrier (1 patient). The male to female techniques have better results, more randomized controlled
ratio was 21 to 7, respectively. Regarding risk factors, trials are needed to achieve statistical significance and more
smoking was present in 53.3%, alcohol consumption in 50%, definite evidence.
and visceral obesity in 53.5% of the cases. The median age
was 65.5 years. 82% of the diagnosed cancer was squamous 133. A SZEROTONINERG MYENTERICUS NEURONOK
cell cancer, while 18% was adenocarcinoma. The most MENNYISÉGÉNEK BÉLSZAKASZ-SPECIFIKUS ÉS
common symptoms were dysphagia (68%) and weight loss INZULIN-FÜGGŐ VÁLTOZÁSAI I. TÍPUSÚ DIABÉTESZES
(81%). Esophageal cancer was more likely to be found in the PATKÁNYOKBAN
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lower (40%) and the middle third (40%) of the esophagus. Szalai Z. , Mezei D. , Barta B. , Balázs J. , Bagyánszki M. ,
The mean weight loss compared to the initial weight was 15 Bódi N.
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(±11) %. 1. Szegedi Tudományegyetem, Természettudományi és
Conclusion: Here we present accurate and detailed data on Informatikai Kar, Élettani, Szervezettani és Idegtudományi
esophageal cancer from our registry, which will provide Tanszék
framework for future cohort analyses and clinical trials.
Introduction: A szerotoninerg neuronok ugyan kis
132. MINIMALLY INVASIVE ESOPHAGECTOMIES ARE populációját teszik ki a myentericus neuronoknak,
MORE BENEFICIAL IN THE TREATMENT OF feltehetően fontosak a tápcsatorna motilitásának
ESOPHAGEAL CANCER THAN OPEN SURGICAL szabályozásában.
TECHNIQUES- A NETWORK META-ANALYSIS. Aims: Kísérleteinkben arra kerestük a választ, hogyan
befolyásolja a krónikus hiperglikémia a 5HT-immunreaktív
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82 Central European Journal of Gastroenterology and Hepatology
Volume 6, Supplementum 2 / November 2020